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Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Received: 10 July 2016     Accepted: 20 July 2016     Published: 22 November 2016
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Abstract

The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)
DOI 10.11648/j.jdmp.20160206.12
Page(s) 67-73
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Physalis peruviana, Antidiabetic, Hydroalcoholic Extract, Streptozotocin, Biochemical Parameters, Wistar Rats

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Cite This Article
  • APA Style

    Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. (2016). Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. Journal of Diseases and Medicinal Plants, 2(6), 67-73. https://doi.org/10.11648/j.jdmp.20160206.12

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    ACS Style

    Felicien M. Kasali; Charles Ntungwen Fokunang; Joseph Ngoupayo; Estella Tembe-Fokunang; Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J. Dis. Med. Plants 2016, 2(6), 67-73. doi: 10.11648/j.jdmp.20160206.12

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    AMA Style

    Felicien M. Kasali, Charles Ntungwen Fokunang, Joseph Ngoupayo, Estella Tembe-Fokunang, Bathelemy Ngameni, et al. Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats. J Dis Med Plants. 2016;2(6):67-73. doi: 10.11648/j.jdmp.20160206.12

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  • @article{10.11648/j.jdmp.20160206.12,
      author = {Felicien M. Kasali and Charles Ntungwen Fokunang and Joseph Ngoupayo and Estella Tembe-Fokunang and Bathelemy Ngameni and Borgia Njinkio and Frederick Kechia and Justin N. Kadima and Tsague Marthe and Oyono Victor and Wilfred Mbacham and Bonaventure Tchaleu Ngadjui},
      title = {Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {2},
      number = {6},
      pages = {67-73},
      doi = {10.11648/j.jdmp.20160206.12},
      url = {https://doi.org/10.11648/j.jdmp.20160206.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.12},
      abstract = {The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats
    AU  - Felicien M. Kasali
    AU  - Charles Ntungwen Fokunang
    AU  - Joseph Ngoupayo
    AU  - Estella Tembe-Fokunang
    AU  - Bathelemy Ngameni
    AU  - Borgia Njinkio
    AU  - Frederick Kechia
    AU  - Justin N. Kadima
    AU  - Tsague Marthe
    AU  - Oyono Victor
    AU  - Wilfred Mbacham
    AU  - Bonaventure Tchaleu Ngadjui
    Y1  - 2016/11/22
    PY  - 2016
    N1  - https://doi.org/10.11648/j.jdmp.20160206.12
    DO  - 10.11648/j.jdmp.20160206.12
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 67
    EP  - 73
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20160206.12
    AB  - The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Department of Pharmacy, Faculty of Medicine and Pharmacy, Official University of Bukavu, Bukavu, Bukavu-Democratic Republic of Congo

  • Department of Pharmaco-Toxicology and pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmaco-Toxicology and pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Bacteriology, Virology, Parasitology and Infctious Diseases, Faculty of Medicines and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmacology, School of Medicine and Health Sciences, University of Rwanda, Butare, Rwanda

  • Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon

  • Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Biochemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon

  • Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

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